Article
Spontaneous immortalization of mouse fibroblasts involves structural changes in senescence inducing protein, mortalin.
Biochemical and biophysical research communications - 30 Nov 1993
Wadhwa R, Kaul S C, Sugimoto Y, Mitsui Y
Abstract excerpt
Mortalin, a novel member of mouse heat shock protein 70 (hsp70) family, is seen to distinguish the cellular mortal and immortal phenotypes by virtue of its cytosolic and perinuclear distribution, respectively. We report here that the cytosolic and perinuclear forms of mortalin from CD1-ICR mouse...
Topics
- 3T3 Cells
- Animals
- Carrier Proteins
- Cell Line
- Cellular Senescence
- Fibroblasts
- Genetic Variation
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred ICR
- Mice, Inbred Strains
- Polymerase Chain Reaction
- Sequence Analysis, DNA