Article
Asp905Tyr polymorphism of protein phosphatase 1 G subunit gene in hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 1997
Shen G Q, Ikegami H, Fujisawa T, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T
Abstract excerpt
A possible pathogenic polymorphism in the gene for the G subunit of the glycogen-associated regulatory form of protein phosphatase 1 (PP1 G subunit), causing an Asp-to-Tyr substitution at codon 905 (Asp905Tyr), has been reported to be associated with insulin resistance and hypersecretion of insulin in the white population. Since marked heterogeneity has been reported in the association of mutations of candidate...
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