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Article

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.

Diabetes - 1 Sept 1998

Xia J, Scherer S W, Cohen P T, Majer M, Xi T, Norman R A, Knowler W C, Bogardus C, Prochazka M

Abstract excerpt

Selected candidate genes have been analyzed in the Pima Indians of Arizona based on evidence that insulin resistance and type 2 diabetes have significant genetic determinants. An amino acid substitution at codon 905 of the glycogen-targeting subunit of type 1 protein phosphatase that regulates skeletal muscle glycogenesis was recently reported to be associated with changes in insulin action in Danish subjects. In...

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PMID: 9726244
DOI: 10.2337/diabetes.47.9.1519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.PMID 9726244Read ↗

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Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.Semantic proximity Read ↗

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A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.Semantic proximity Read ↗

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