Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.

Diabetes - 1 Sept 1998

Xia J, Scherer S W, Cohen P T, Majer M, Xi T, Norman R A, Knowler W C, Bogardus C, Prochazka M

Abstract excerpt

Selected candidate genes have been analyzed in the Pima Indians of Arizona based on evidence that insulin resistance and type 2 diabetes have significant genetic determinants. An amino acid substitution at codon 905 of the glycogen-targeting subunit of type 1 protein phosphatase that regulates sk...

Topics

Adult
Alleles
Arizona
Base Sequence
Codon
Diabetes Mellitus, Type 2
Female
Genetic Variation
Genotype
Humans
Indians, North American
Insulin Resistance
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Muscle, Skeletal

Phosphoprotein Phosphatases

Polymorphism, Genetic

RNA, Messenger

Source

Identifiers

PMID: 9726244
DOI: 10.2337/diabetes.47.9.1519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9726244-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes.PMID 9726244Read ↗

The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.Semantic proximity Read ↗

Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians.Semantic proximity Read ↗

The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus.Semantic proximity Read ↗

Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.Semantic proximity Read ↗

Single nucleotide polymorphisms within functional regions of genes implicated in insulin action and association with the insulin resistant phenotype.Semantic proximity Read ↗

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.Semantic proximity Read ↗

[Study on association of PPP1R3 gene 5 bp deletion/insertion within 3'-untranslated region polymorphism with type 2 diabetes].Semantic proximity Read ↗

A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistanceSemantic proximity Read ↗

Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.Semantic proximity Read ↗

Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes.Semantic proximity Read ↗

Somatic mutations and genetic polymorphisms of the PPP1R3 gene in patients with several types of cancers.Semantic proximity Read ↗

[Study on the association of PPP1R3 gene polymorphism with type 2 diabetes in Han population of Anhui province].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.