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Article

Evaluation of an antisense RNA transgene for inhibiting growth hormone gene expression in transgenic rats.

Developmental genetics - 1 Jan 1995

Matsumoto K, Kakidani H, Anzai M, Nakagata N, Takahashi A, Takahashi Y, Miyata K

Abstract excerpt

We compared the levels of growth hormone (GH) mRNA in the pituitary, plasma GH concentration, and altered phenotype in rats heterozygous and homozygous for an antisense RNA transgene targeted to the rat GH gene, with those in nontransgenic rats. We initially investigated whether the transgene promoter, which is connected to four copies of a thyroid hormone response element (TRE) that increases promoter activity,...

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PMID: 7796536
DOI: 10.1002/dvg.1020160307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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