Article
Evaluation of an antisense RNA transgene for inhibiting growth hormone gene expression in transgenic rats.
Developmental genetics - 1 Jan 1995
Matsumoto K, Kakidani H, Anzai M, Nakagata N, Takahashi A, Takahashi Y, Miyata K
Abstract excerpt
We compared the levels of growth hormone (GH) mRNA in the pituitary, plasma GH concentration, and altered phenotype in rats heterozygous and homozygous for an antisense RNA transgene targeted to the rat GH gene, with those in nontransgenic rats. We initially investigated whether the transgene pro...
Topics
- Animals
- Animals, Genetically Modified
- Body Weight
- Female
- Gene Expression
- Gene Targeting
- Growth Hormone
- Heterozygote
- Homozygote
- Male
- Phenotype
- Pituitary Gland
- RNA, Antisense
- RNA, Messenger
- Rats
- Thyroidectomy
- Triiodothyronine