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Article

Molecular Regulation of Atrioventricular Valvuloseptal Morphogenesis

1 Jul 1995

Abstract excerpt

The majority of congenital heart defects arise from abnormal development of valvuloseptal tissue. The primordia of the valve leaflets and membranous septa of the heart are the cardiac cushions. Remodeling of the cushions is associated with a transitional extracellular matrix that includes sulfated proteoglycans and the microfibrillar proteins fibulin and fibrillin. Cushion formation is restricted to the AV canal...

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Identifiers

PMID: 7788867
DOI: 10.1161/01.res.77.1.1

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