Article
Essential Cys-Pro-Cys motif of Caenorhabditis elegans copper transport ATPase.
Bioscience, biotechnology, and biochemistry - 1 Jun 1998
Yoshimizu T, Omote H, Wakabayashi T, Sambongi Y, Futai M
Abstract excerpt
Caenorhabditis elegans putative copper ATPase (CUA-1) had been functionally expressed in a yeast delta ccc2 mutant (copper ATPase gene disruptant). We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast delta ccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is essential for copper transport.
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Biological Transport
- Caenorhabditis elegans
- Copper
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid