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Article

Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.

Oncogene - 15 Jun 1995

Ahn M J, Nason-Burchenal K, Moasser M M, Dmitrovsky E

Abstract excerpt

The balanced t(15;17) rearrangement found in acute promyelocytic leukemia (APL) cells fuses PML on chromosome 15 to the retinoic acid receptor alpha (RAR alpha) on chromosome 17. PML/RAR alpha is expressed in APL cells with the non-rearranged alleles, PML and RAR alpha. Clinical remissions induced by all-trans-retinoic acid (RA) treatment of APL patients are linked to expression of PML/RAR apha, a transcription...

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Source

Identifiers

PMID: 7784078

Genes

PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.PMID 7784078Read ↗

The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cellsSemantic proximity Read ↗

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A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα MutationSemantic proximity Read ↗

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLSemantic proximity Read ↗

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.Semantic proximity Read ↗

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.Semantic proximity Read ↗

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.Semantic proximity Read ↗

Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia.Semantic proximity Read ↗

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