Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.

Oncogene - 15 Jun 1995

Ahn M J, Nason-Burchenal K, Moasser M M, Dmitrovsky E

Abstract excerpt

The balanced t(15;17) rearrangement found in acute promyelocytic leukemia (APL) cells fuses PML on chromosome 15 to the retinoic acid receptor alpha (RAR alpha) on chromosome 17. PML/RAR alpha is expressed in APL cells with the non-rearranged alleles, PML and RAR alpha. Clinical remissions induced by all-trans-retinoic acid (RA) treatment of APL patients are linked to expression of PML/RAR apha, a transcription...

Topics

Alleles
Base Sequence
Cell Differentiation
Cell Division
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Cinnamates
Drug Resistance
Humans
Hygromycin B
Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Neomycin

Neoplasm Proteins

Nuclear Proteins

Oncogene Proteins, Fusion

Polymerase Chain Reaction

Promyelocytic Leukemia Protein

Source

Open in PubMed

Identifiers

PMID: 7784078

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7784078-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.PMID 7784078Read ↗

The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cellsSemantic proximity Read ↗

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.Semantic proximity Read ↗

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα MutationSemantic proximity Read ↗

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLSemantic proximity Read ↗

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.Semantic proximity Read ↗

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.Semantic proximity Read ↗

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.Semantic proximity Read ↗

Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia.Semantic proximity Read ↗

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.Semantic proximity Read ↗

Detection of minimal residual disease in acute promyelocytic leukemia by a reverse transcription polymerase chain reaction assay for the PML/RAR-alpha fusion mRNASemantic proximity Read ↗

A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.Semantic proximity Read ↗

C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.