Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.

The EMBO journal - 3 Nov 2003

Duprez Estelle, Wagner Katharina, Koch Heike, Tenen Daniel G

Abstract excerpt

In acute promyelocytic leukemia (APL), the translocation t(15;17) induces a block at the promyelocytic stage of differentiation in an all-trans-retinoic acid (ATRA)-responsive manner. Here we report that upon treatment with ATRA, t(15;17) cells (NB4) reveal a very rapid increase in protein level and binding activity of C/EBPbeta, a C/EBP family member, which was not observed in an ATRA-resistant NB4 cell line. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-beta
Share to Hematopoiesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to K562 Cells

Share to Leukemia, Promyelocytic, Acute

Share to Oncogene Proteins, Fusion

Share to RNA, Neoplasm

Share to Tretinoin

Share to U937 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 14592978
DOI: 10.1093/emboj/cdg556
PMCID: PMC275413

Genes

PML
RARA
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.PMID 14592978Read ↗

Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodiesSemantic proximity Read ↗

Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.Semantic proximity Read ↗

CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.Semantic proximity Read ↗

Identification of a new cryptic PML-RARα fusion gene without t(15;17) and biallelic CEBPA mutation in a case of acute promyelocytic leukemia: a case detected only by RT-PCR but not cytogenetics and FISH.Semantic proximity Read ↗

ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expressionSemantic proximity Read ↗

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLSemantic proximity Read ↗

Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein.Semantic proximity Read ↗

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.Semantic proximity Read ↗

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα MutationSemantic proximity Read ↗

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)Semantic proximity Read ↗

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.Semantic proximity Read ↗

BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.