Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia.

Article

Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia.

Oncology (Williston Park, N.Y.) - 1 Aug 1992

Frankel S R, Miller W H, Dmitrovsky E

Abstract excerpt

All-trans retinoic acid can induce complete remissions in patients with acute promyelocytic leukemia. The balanced chromosomal translocation t(15;17)(q22;q12-21) of this malignancy is now known to involve the nuclear retinoic acid receptor-alpha (RAR-alpha) on the long arm of chromosome 17 and a...

Topics

Animals
Carrier Proteins
Clinical Trials as Topic
Humans
Leukemia, Promyelocytic, Acute
Mutation
Receptors, Retinoic Acid
Tretinoin

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