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Article

[The critical significance of a conserved single-stranded interdomain linker in the 5'-untranslated region of poliovirus RNA].

Molekuliarnaia biologiia - 1 Jan 2000

Belov G A, Gmyl' A P, Maslova S V, Pilipenko E V, Agol V I

Abstract excerpt

Translation of polioviral RNA is initiated by interaction of a small ribosomal subunit with internal segments of the 5'-untranslated region (5'UTR). Several mutations were constructed within 5'UTR segment 425-449. All of them (including a single C444-->U replacement) inhibited in vitro translation, which decreased about 10-fold. Two mutant constructs, pPV12-05 (C444-->U) and pPV12K (containing also an AAUU insert...

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PMID: 7783735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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