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Article

The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.

Development (Cambridge, England) - 1 Jan 2009

Mann Tabea, Bodmer Rolf, Pandur Petra

Abstract excerpt

In mouse, the LIM-homeodomain transcription factor Islet1 (Isl1) has been shown to demarcate a separate cardiac cell population that is essential for the formation of the right ventricle and the outflow tract of the heart. Whether Isl1 plays a crucial role in the early regulatory network of transcription factors that establishes a cardiac fate in mesodermal cells has not been fully resolved. We have analyzed the...

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Identifiers

PMID: 19088091
DOI: 10.1242/dev.022533
PMCID: PMC2685972

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