Article
Activating transcription factor-1 is a specific antagonist of the cyclic adenosine 3'.5'-monophosphate (cAMP) response element-binding protein-1-mediated response to cAMP.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 1995
Ellis M J, Lindon A C, Flint K J, Jones N C, Goodbourn S
Abstract excerpt
We have investigated the molecular basis of the variability of the somatostatin cAMP response element (CRE) function in different cell lines. All cells tested contain detectable levels of the CRE-binding protein CREB-1, which mediates transactivation in response to the cAMP-dependent protein kina...
Topics
- Activating Transcription Factor 1
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Cyclic AMP
- Cyclic AMP Response Element-Binding Protein
- Cyclic AMP-Dependent Protein Kinases
- DNA-Binding Proteins
- Down-Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Recombinant Fusion Proteins