Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.

doi:10.1016/0021-9150(94)05402-5

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Article

Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.

Atherosclerosis - 6 Jan 1995

Hanlon C S, Rubinsztein D C

Abstract excerpt

Apolipoprotein E is a secretory glycoprotein that associates with lipoprotein particles and is coded for by a single locus on chromosome 19. The three common allelic isoforms of this protein (apo E2, apo E3 and apo E4) are associated with distinct patterns of lipoprotein metabolism and variable risks for coronary artery disease. In addition, recent work has shown that the presence of the apo E4 isoform...

Topics

Alleles
Amino Acid Sequence
Animals
Apolipoproteins E
Arginine
Base Sequence
Biological Evolution
Cercopithecidae
Codon
Female
Gorilla gorilla
Haplorhini

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Macaca fascicularis

Macaca mulatta

Male

Molecular Sequence Data

Pan troglodytes

Source

Open in PubMed

Identifiers

PMID: 7772071
DOI: 10.1016/0021-9150(94)05402-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7772071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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