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Article

Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.

Leukemia - 1 Aug 2009

Jeha S, Pei D, Raimondi S C, Onciu M, Campana D, Cheng C, Sandlund J T, Ribeiro R C, Rubnitz J E, Howard S C, Downing J R, Evans W E, Relling M V, Pui C-H

Abstract excerpt

To evaluate the impact of contemporary therapy on the clinical outcome of children with pre-B acute lymphoblastic leukemia (ALL) and the t(1;19)/TCF3/PBX1, we analyzed 735 patients with B-cell precursor ALL treated in four successive protocols at St Jude Children's Research Hospital. The 41 patients with the t(1;19) had a comparable event-free survival to that of the 694 patients with other B-cell precursor ALL...

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Source

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Identifiers

PMID: 19282835
DOI: 10.1038/leu.2009.42
PMCID: PMC2731684

Genes

PBX1
TCF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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