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Article

Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes.

Journal of virology - 1 Jul 1995

Simm M, Shahabuddin M, Chao W, Allan J S, Volsky D J

Abstract excerpt

Productive, spreading infection of peripheral blood lymphocytes (PBL) with human immunodeficiency virus type 1 (HIV-1) requires the viral protein Vif. To study the requirement for vif in this system, we infected PBL with a phenotypically complemented HIV-1 clone mutated in vif. Progeny virus was produced which was noninfectious in PBL but replicated in SupT1 cells. Analysis of metabolically labeled proteins of...

Topics

Gene Products, gag
Gene Products, vif
HIV-1
Humans
Lymphocytes
Mutation
Protein Precursors
vif Gene Products, Human Immunodeficiency Virus

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7769728
DOI: 10.1128/JVI.69.7.4582-4586.1995
PMCID: PMC189210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769728-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes.PMID 7769728Read ↗

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