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Article

HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes.

Virology - 1 Mar 2008

Goila-Gaur Ritu, Khan Mohammad A, Miyagi Eri, Kao Sandra, Opi Sandrine, Takeuchi Hiroaki, Strebel Klaus

Abstract excerpt

HIV-1 Vif inhibits the antiviral activity of APOBEC3G (APO3G) by inducing proteasomal degradation. Here, we studied the effects of Vif on APO3G in vitro. In this system, Vif did not cause APO3G degradation. Instead, Vif induced changes in APO3G that affected immunoprecipitation of the native protein. This effect required wt Vif and was reversed by heat denaturation of APO3G. Sucrose gradient analysis demonstrated...

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Share to vif Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 18023836
DOI: 10.1016/j.virol.2007.10.017
PMCID: PMC2396953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes.PMID 18023836Read ↗

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