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Article

Intravirion processing of the human immunodeficiency virus type 1 Vif protein by the viral protease may be correlated with Vif function.

Journal of virology - 1 Sept 2002

Khan Mohammad A, Akari Hirofumi, Kao Sandra, Aberham Claudia, Davis David, Buckler-White Alicia, Strebel Klaus

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Vif protein is specifically packaged into virus particles through an interaction with viral genomic RNA in which it associates with the viral nucleoprotein complex. We now demonstrate for the first time that virus-associated Vif is subject to proteolytic processing by the viral protease (Pr). Pr-dependent processing of Vif was observed both in vivo and in vitro. In...

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Identifiers

PMID: 12186895
DOI: 10.1128/jvi.76.18.9112-9123.2002
PMCID: PMC136454

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Source receipt: pubmed, retrieved 7 Sept 2026.

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