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Article

Familial and sporadic human renal cell carcinoma: evidence against a double-loss mechanism of carcinogenesis.

Journal of clinical epidemiology - 1 Jun 1995

Stein W D, Stein A D

Abstract excerpt

It has been speculated that renal cell carcinoma (RCC) is an example of a double-loss mutation. We analyzed the age distribution of 71 cases of familial RCC and of 11 population-based cancer registries [German Democratic Republic, Denmark, Finland, Norway, Sweden, U.S.A. Whites, U.S.A. Blacks, Miyagi and Osaka Prefectures (Japan), Hong Kong, and Israeli Jews] according to the multi-hit and clonal growth models of...

Topics

Adult
Age Distribution
Aged
Carcinoma, Renal Cell
Female
Humans
Incidence
Kidney Neoplasms
Male
Middle Aged
Models, Genetic
Mutation

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Identifiers

PMID: 7769407
DOI: 10.1016/0895-4356(94)00192-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769407-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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