Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial and sporadic human renal cell carcinoma: evidence against a double-loss mechanism of carcinogenesis.

Journal of clinical epidemiology - 1 Jun 1995

Stein W D, Stein A D

Abstract excerpt

It has been speculated that renal cell carcinoma (RCC) is an example of a double-loss mutation. We analyzed the age distribution of 71 cases of familial RCC and of 11 population-based cancer registries [German Democratic Republic, Denmark, Finland, Norway, Sweden, U.S.A. Whites, U.S.A. Blacks, Miyagi and Osaka Prefectures (Japan), Hong Kong, and Israeli Jews] according to the multi-hit and clonal growth models of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution
Share to Aged
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Incidence

Share to Kidney Neoplasms

Share to Models, Genetic

Share to Mutation

Share to Registries

Source

Identifiers

PMID: 7769407
DOI: 10.1016/0895-4356(94)00192-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial and sporadic human renal cell carcinoma: evidence against a double-loss mechanism of carcinogenesis.PMID 7769407Read ↗

Kidney cancer: Links between hereditary syndromes and sporadic tumorigenesisSemantic proximity Read ↗

Familial papillary renal cell tumors and subsequent cancers: a nationwide epidemiological study from Sweden.Semantic proximity Read ↗

Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma.Semantic proximity Read ↗

Origin of renal cell carcinomas.Semantic proximity Read ↗

Familial renal cell carcinoma from the Swedish Family-Cancer Database.Semantic proximity Read ↗

Understanding familial and non-familial renal cell cancerSemantic proximity Read ↗

Autosomal dominant polycystic kidney disease: a two-hit model.Semantic proximity Read ↗

Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview.Semantic proximity Read ↗

Risk of bilateral renal cell cancer.Semantic proximity Read ↗

[Prevention of renal carcinoma: the nutri-genetic approach].Semantic proximity Read ↗

Family history and risk of renal cell carcinoma.Semantic proximity Read ↗

Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.