Article
Origin of renal cell carcinomas.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Nov 2008
Valladares Ayerbes Manuel, Aparicio Gallego Guadalupe, Díaz Prado Silvia, Jiménez Fonseca Paula, García Campelo Rosario, Antón Aparicio Luis Miguel
Abstract excerpt
Cancer is a heritable disorder of somatic cells: environment and heredity are both important in the carcinogenic process. The primal force is the "two hits" of Knudson's hypothesis, which has proved true for many tumours, including renal cell carcinoma. Knudson et al. [1, 2] recognised that familial forms of cancer might hold the key to the identification of important regulatory elements known as...
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