Article
Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma.
Journal of medical genetics - 1 May 1990
Maher E R, Yates J R, Ferguson-Smith M A
Abstract excerpt
Analysis of the age incidence curves for unilateral and bilateral retinoblastoma led Knudson to propose that hereditary tumours may arise by a single event and sporadic tumours by a two stage mutation process. It has been suggested recently that sporadic renal cell carcinoma may arise from a two stage mutation process. We analysed the age incidence curves for symptomatic renal cell carcinoma (n = 26) and...
Topics
- Adult
- Aged
- Angiomatosis
- Carcinoma, Renal Cell
- Cerebellar Neoplasms
- Female
- Hemangiosarcoma
- Humans
- Incidence
- Kidney Neoplasms
- Male
- Middle Aged