Article
Natural variants of the beta isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids.
Molecular and cellular endocrinology - 20 Jul 1999
de Lange P, Koper J W, Brinkmann A O, de Jong F H, Lamberts S W
Abstract excerpt
The beta isoform of the human glucocorticoid receptor, hGRbeta, is a product of alternative splicing of the hGR gene. The physiological function of this isoform is unknown up to now. Recent data are contradictory in that they either favor or argue against a role of hGRbeta as a repressor of the functional hGRalpha isoform. In the present study hGRbeta did not inhibit transcriptional activation of the MMTV-driven...
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