Pregnancy-dependent to ovarian-independent progression in mammary tumors delineated in primary culture: changes in signal transduction, growth factor regulation, and matrix interaction.

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Article

Pregnancy-dependent to ovarian-independent progression in mammary tumors delineated in primary culture: changes in signal transduction, growth factor regulation, and matrix interaction.

Cancer research - 1 Dec 1992

Imagawa W, Bandyopadhyay G K, Garcia M, Matsuzawa A, Nandi S

Abstract excerpt

A model for the evolution of hormone-independent tumors from a pregnancy-dependent precursor is exemplified by the TPDMT-4[pregnancy-dependent (PD)] and T4OI96 [ovarian-independent (OI)] in vivo tumor lines developed in DDD mice. In vivo, the OI tumor grows rapidly in virgin mice and is more anap...

Topics

Animals
Cell Division
Culture Media, Serum-Free
Cyclic AMP
Dinoprostone
Drug Synergism
Epidermal Growth Factor
Female
Fibroblast Growth Factor 2
Growth Substances
Insulin
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linoleic Acid

Linoleic Acids

Mammary Neoplasms, Experimental

Mice

Neoplasms, Hormone-Dependent

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1330295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1330295-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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