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Article

A nonparametric approach for mapping quantitative trait loci.

Genetics - 1 Mar 1995

Kruglyak L, Lander E S

Abstract excerpt

Genetic mapping of quantitative trait loci (QTLs) is performed typically by using a parametric approach, based on the assumption that the phenotype follows a normal distribution. Many traits of interest, however, are not normally distributed. In this paper, we present a nonparametric approach to QTL mapping applicable to any phenotypic distribution. The method is based on a statistic ZW, which generalizes the...

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Identifiers

PMID: 7768449
DOI: 10.1093/genetics/139.3.1421
PMCID: PMC1206467

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