Apoptotic cell death increases with senescence in normal human dermal fibroblast cultures

doi:10.1016/j.cellbi.2006.06.010

Article

Apoptotic cell death increases with senescence in normal human dermal fibroblast cultures

4 Jul 2006

Abstract excerpt

Normal human dermal fibroblasts have a limited life-span in vitro and stop proliferation after a fixed number of cell divisions. This process by which cells stop proliferation is called senescence. Senescence is also characterized by a decrease in the total cell number. In this study, we characterized an increase in cell death in normal human dermal fibroblasts in vitro as a function of increasing cell passage....

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