Article
The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells.
Cancer research - 1 Jun 1995
Lutchman M, Rouleau G A
Abstract excerpt
Cancer is a multistep process that involves the activation of oncogenes and the inactivation of antioncogenes. Recently, a new putative tumor suppressor, the neurofibromatosis type 2 (NF2) gene, was mapped to chromosome 22, cloned, and found to encode for a new protein, merlin/schwannomin, a member of the band 4.1 family of proteins. Members of this family have not been implicated previously in tumorigenesis....
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