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Article

BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 1995

Ahmed S, Reynolds B A, Weiss S

Abstract excerpt

We have previously reported the isolation of an EGF-responsive precursor from the embryonic and adult mouse striatum. This precursor exhibits self renewal and the ability to produce a sphere of undifferentiated cells which can be induced to differentiate into neurons and glia. RT-PCR analysis of these spheres of undifferentiated cells revealed the expression of mRNA for the trkB neurotrophin receptor, both with...

Topics

Animals
Brain-Derived Neurotrophic Factor
Cell Count
Cell Differentiation
Cell Survival
Cells, Cultured
Central Nervous System
Epidermal Growth Factor
Mice
Nerve Growth Factors
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurites

Neurons

Phenotype

Stem Cells

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 7643217
PMCID: PMC6577638

Genes

BDNF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7643217-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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