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Article

Matrix mineralization and the differentiation of osteocyte-like cells in culture.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 1995

Mikuni-Takagaki Y, Kakai Y, Satoyoshi M, Kawano E, Suzuki Y, Kawase T, Saito S

Abstract excerpt

Osteocyte-like cells were prepared by sequentially treating calvaria from newborn rats with collagenase and chelating agents. On a reconstituted gel of basement membrane components, cells from the third collagenase digest displayed a round shape and expressed the highest level of alkaline phosphatase with minimal osteocalcin deposition into the matrix. On the other hand, cells derived from the interior after EDTA...

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Source

Identifiers

PMID: 7754802
DOI: 10.1002/jbmr.5650100209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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