Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease.

doi:10.1016/0022-510x(94)00249-n

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Article

Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease.

Journal of the neurological sciences - 1 Mar 1995

Yamada T, Kondo A, Takamatsu J, Tateishi J, Goto I

Abstract excerpt

To clarify the role of apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), we used an RT-PCR method to investigate apoE and glial fibrillary acidic protein (GFAP) mRNA expression in the brain. ApoE mRNA was significantly more abundant in AD (0.379 +/- 0.191, mean +/- SD) t...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Base Sequence
Brain
Female
Glial Fibrillary Acidic Protein
Humans
Male
Middle Aged
Molecular Probes
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Messenger

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