Article
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
FEBS letters - 8 May 1995
Doza Y N, Cuenda A, Thomas G M, Cohen P, Nebreda A R
Abstract excerpt
A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phos...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- DNA, Complementary
- Enzyme Activation
- Humans
- Intracellular Signaling Peptides and Proteins
- Molecular Sequence Data
- Mutation
- Peptide Fragments