Article
Structure-function correlates of human high molecular weight kininogen.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Aug 1994
Colman R W
Abstract excerpt
1. The first documented mutation responsible for total human kininogen deficiency has been characterized as a single base change from CGA to TGA in exon 5, resulting in an Arg-->Stop mutation inherited as an autosomal recessive trait. 2. The surface binding domain (D5) of high molecular weight kininogen (HK) was mapped by deletion mutagenesis into two regions, the first rich in histidine and glycine, and the...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cattle
- Humans
- Kininogens
- Models, Chemical
- Molecular Sequence Data
- Mutation
- Pedigree
- Protein Conformation
- Rats