Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1.

doi:10.1128/JVI.69.4.2596-2601.1995

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Article

Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1.

Journal of virology - 1 Apr 1995

Haller O, Frese M, Rost D, Nuttall P A, Kochs G

Abstract excerpt

We show that tick-transmitted Thogoto virus is sensitive to interferon-induced nuclear Mx1 protein, which is known for its specific antiviral action against orthomyxoviruses. Influenza virus-susceptible BALB/c mice (lacking a functional Mx1 gene) developed severe disease symptoms and died within...

Topics

Animals
Antiviral Agents
Embryo, Mammalian
GTP-Binding Proteins
Liver
Macrophages, Peritoneal
Mice
Mice, Inbred Strains
Myxovirus Resistance Proteins
Orthomyxoviridae Infections
Phenotype
Proteins
Thogotovirus
Virus Replication

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