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A RNA Dodecahedral Cage Inside a Human Virus Plays a Dual Biological Role in Virion Assembly and Genome Release Control

25 Dec 2024

Abstract excerpt

• A RNA dodecahedral cage inside a human virus is a multifunctional structural element. • Interactions between the viral capsid and RNA duplexes promote virus infection. • Structurally discrete subsets of capsid-RNA interactions control different processes. • A subset of RNA-duplex interactions facilitates virion assembly. • A second subset of RNA-duplex interactions modulates viral RNA genome uncoating. Human...

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PMID: 39725271
DOI: 10.1016/j.jmb.2024.168922

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