Article
Two mutations in the vif gene of maedi-visna virus have different phenotypes, indicating more than one function of Vif.
Virology - 15 Jan 2016
Franzdóttir Sigrídur R, Ólafsdóttir Katrín, Jónsson Stefán R, Strobel Hannah, Andrésson Ólafur S, Andrésdóttir Valgerdur
Abstract excerpt
Like most other lentiviruses, maedi-visna virus (MVV) requires Vif for replication in natural target cells and in vivo. Here, we show that Vif-deficient MVV accumulates G-A mutations in the sequence context characteristic of ovine APOBEC3, consistent with a role of MVV Vif in neutralizing APOBEC3. We studied two point mutations in the vif gene of MVV. One was a tryptophan to arginine mutation that affects the...
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