Article
A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.
Molecular and cellular biology - 1 Mar 1992
Costigan C, Gehrung S, Snyder M
Abstract excerpt
The Saccharomyces cerevisiae SPA2 protein localizes at sites involved in polarized cell growth in budding cells and mating cells. spa2 mutants have defects in projection formation during mating but are healthy during vegetative growth. A synthetic lethal screen was devised to identify mutants tha...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Cytoskeletal Proteins
- DNA, Fungal
- Fungal Proteins
- Genes, Lethal
- Genes, Suppressor
- Genetic Complementation Test
- Meiosis
- Mitogen-Activated Protein Kinase Kinases
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Phenotype
- Pheromones
- Protein Kinases
- Restriction Mapping