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Article

A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.

Molecular and cellular biology - 1 Mar 1992

Costigan C, Gehrung S, Snyder M

Abstract excerpt

The Saccharomyces cerevisiae SPA2 protein localizes at sites involved in polarized cell growth in budding cells and mating cells. spa2 mutants have defects in projection formation during mating but are healthy during vegetative growth. A synthetic lethal screen was devised to identify mutants that require the SPA2 gene for vegetative growth. One mutant, called slk-1 (for synthetic lethal kinase), has been...

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Identifiers

PMID: 1545797
DOI: 10.1128/mcb.12.3.1162-1178.1992
PMCID: PMC369547

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