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Article

Significance of <i>HDMX</i>‐S (or <i>MDM4</i>) mRNA splice variant overexpression and <i>HDMX</i> gene amplification on primary soft tissue sarcoma prognosis

19 May 2005

Abstract excerpt

The product of the HDMX (or MDM4) gene is structurally related to the MDM2 oncoprotein and is also capable of interacting with the tumor suppressor protein p53. The aim of our study was to determine the amplification status of the HDMX gene and the expression of the HDMX mRNA (particularly that of the HDMX-S splice variant) in soft-tissue sarcomas (STS). Patients with STS were evaluated for the status of HDMX...

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Identifiers

PMID: 15906355
DOI: 10.1002/ijc.21206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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