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Article

A mechanical function of myosin II in cell motility.

Journal of cell science - 1 Jan 1995

Jay P Y, Pham P A, Wong S A, Elson E L

Abstract excerpt

Myosin II mutant Dictyostelium amoebae crawl more slowly than wild-type cells. Thus, myosin II must contribute to amoeboid locomotion. We propose that contractile forces generated by myosin II help the cell's rear edge to detach from the substratum and retract, allowing the cell to continue forward. To test this hypothesis, we measured the speed of wild-type and myosin II null mutant Dictyostelium cells on...

Topics

Animals
Cell Adhesion
Cell Movement
Dictyostelium
Microscopy, Interference
Models, Biological
Mutation
Myosins
Organelles
Polylysine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7738114
DOI: 10.1242/jcs.108.1.387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7738114-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A mechanical function of myosin II in cell motility.PMID 7738114Read ↗

Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movement.Semantic proximity Read ↗

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility.Semantic proximity Read ↗

How a cell crawls and the role of cortical myosin II.Semantic proximity Read ↗

Mutants lacking myosin II cannot resist forces generated during multicellular morphogenesis.Semantic proximity Read ↗

Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions.Semantic proximity Read ↗

Three-dimensional localization of wild-type and myosin II mutant cells during morphogenesis of Dictyostelium.Semantic proximity Read ↗

Myosin II can be localized to the cleavage furrow and to the posterior region of Dictyostelium amoebae without control by phosphorylation of myosin heavy and light chains.Semantic proximity Read ↗

Shared, unique and redundant functions of three members of the class I myosins (MyoA, MyoB and MyoF) in motility and chemotaxis in Dictyostelium.Semantic proximity Read ↗

Cell-substrate interactions and locomotion of Dictyostelium wild-type and mutants defective in three cytoskeletal proteins: a study using quantitative reflection interference contrast microscopy.Semantic proximity Read ↗

In vivo observations of myosin II dynamics support a role in rear retraction.Semantic proximity Read ↗

Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments.Semantic proximity Read ↗

Myosin-II-mediated directional migration of Dictyostelium cells in response to cyclic stretching of substratum.Semantic proximity Read ↗

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