Article
Developmental regulation of antisense-mediated gene silencing in Dictyostelium.
Antisense research and development - 1 Jan 1994
Sadiq M, Hildebrandt M, Maniak M, Nellen W
Abstract excerpt
In Dictyostelium, the expression of antisense transcripts has been successfully used to reduce or eliminate gene expression. In most cases this occurs on the level of RNA stability resulting in a loss of both sense and antisense transcript accumulation. We here show that the antisense effect is regulated during the developmental cycle, i.e., in certain developmental stages and under certain developmental...
Topics
- Animals
- Cyclic AMP
- Dictyostelium
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Fungal
- Mutation
- RNA, Antisense
- Spores, Fungal