Article
Xenopus laevis: a model system for the study of embryonic retinoid metabolism. II. Embryonic metabolism of all-trans-3,4-didehydroretinol to all-trans-3,4-didehydroretinoic acid.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 1995
Creech Kraft J, Kimelman D, Juchau M R
Abstract excerpt
This study demonstrates early embryonic metabolism of exogenous all-trans-3,4-didehydroretinol (vitamin A2) to all-trans-3,4-didehydroretinal and to all-trans-3,4-didehydroretinoic acid in Xenopus embryos during neurulation. The latter metabolite was recently shown to bind with high affinity and...
Topics
- Abnormalities, Drug-Induced
- Animals
- Chromatography, High Pressure Liquid
- Embryo, Nonmammalian
- Female
- Phenotype
- Teratogens
- Tretinoin
- Vitamin A
- Xenopus laevis