Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of vitamin A in mammalian reproduction and embryonic development.

Annual review of nutrition - 1 Jan 2002

Clagett-Dame Margaret, DeLuca Hector F

Abstract excerpt

Since the late 1980s, there has been an explosion of information on the molecular mechanisms and functions of vitamin A. This review focuses on the essential role of vitamin A in female reproduction and embryonic development and the metabolism of vitamin A (retinol) that results in these functions. Evidence strongly supports that in situ-generated all-trans retinoic acid (atRA) is the functional form of vitamin A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Animal
Share to Aldehyde Oxidoreductases
Share to Diet

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryonic and Fetal Development

Share to Receptors, Retinoic Acid

Share to Reproduction

Share to Retinal Dehydrogenase

Share to Vitamin A

Source

Identifiers

PMID: 12055350
DOI: 10.1146/annurev.nutr.22.010402.102745E

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of vitamin A in mammalian reproduction and embryonic development.PMID 12055350Read ↗

Vitamin A prevents inner ear defects in mice with congenital homeobox gene deficiency.Semantic proximity Read ↗

A paradoxical teratogenic mechanism for retinoic acidSemantic proximity Read ↗

Chronicle of a discovery: the retinoic acid receptorSemantic proximity Read ↗

Developmental roles of the retinoic acid receptors.Semantic proximity Read ↗

A nutritional model of late embryonic vitamin A deficiency produces defects in organogenesis at a high penetrance and reveals new roles for the vitamin in skeletal developmentSemantic proximity Read ↗

[Genetic control of the development by retinoic acid].Semantic proximity Read ↗

Function of Retinoic Acid in Development of Male and Female GametesSemantic proximity Read ↗

Genetics and functions of the retinoic acid pathway, with special emphasis on the eye.Semantic proximity Read ↗

Embryonic phenotype, β-carotene and retinoid metabolism upon maternal supplementation of β-carotene in a mouse model of severe vitamin A deficiency.Semantic proximity Read ↗

Vitamin A Deficiency and Alterations in the Extracellular MatrixSemantic proximity Read ↗

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.Semantic proximity Read ↗

Embryonic development and pattern formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.