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Article

Teratogenicity of all‐<i>trans</i> retinoic acid during early embryonic development in the cynomolgus monkey (<i>Macaca fascicularis</i>)

1 Jan 1992

Abstract excerpt

The embryotoxic and teratogenic potential of all-trans retinoic acid was assessed following exposure prior to and during early organogenesis in the cynomolgus monkey (Macaca fascicularis). Sixteen pregnant females were orally administered all-trans retinoic acid (Tretinoin, Hoffmann-La Roche) once daily from GD 10-20 and twice daily from GD 21-24 at three different dosages, 5 (n = 9), 10 (n = 6) and 20 mg/kg (n =...

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Identifiers

PMID: 1731397
DOI: 10.1002/tera.1420450106

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