Article
Protein kinase A inhibits a consolidated form of memory in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2008
Horiuchi Junjiro, Yamazaki Daisuke, Naganos Shintaro, Aigaki Toshiro, Saitoe Minoru
Abstract excerpt
Increasing activity of the cAMP/protein kinase A (PKA) pathway has often been proposed as an approach to improve memory in various organisms. However, here we demonstrate that single-point mutations, which decrease PKA activity, dramatically improve aversive olfactory memory in Drosophila. These mutations do not affect formation of early memory phases or of protein synthesis-dependent long-term memory but do...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.