Article
Response of heat shock element within the human HSP70 promoter to mutated p53 genes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1995
Tsutsumi-Ishii Y, Tadokoro K, Hanaoka F, Tsuchida N
Abstract excerpt
Recent studies have demonstrated that mutation of the p53 gene caused a gain of new functions such as transforming activation, binding to heat shock cognate protein 70 and/or transactivation of a variety of promoters. In the course of seeking the biochemical basis for the gain of these functions,...
Topics
- Base Sequence
- Cell Line
- Cell Transformation, Neoplastic
- Gene Deletion
- Genes, p53
- HSP70 Heat-Shock Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Point Mutation
- Promoter Regions, Genetic
- Protein Binding
- Transcriptional Activation