Article
A method for estimating cancer risk in p53 mutation carriers.
Cancer detection and prevention - 1 Jan 1994
Le Bihan C, Bonaiti-Pellie C
Abstract excerpt
Germline mutations of the tumor-suppressor gene p53 have been described in families with multiple neoplasms as Li-Fraumeni syndrome families, or in subjects with second malignant tumor. In order to evaluate the increase in risk of cancer due to these mutations, a family study is being carried out...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Genes, p53
- Heterozygote
- Humans
- Infant
- Infant, Newborn
- Middle Aged
- Mutation
- Neoplasms
- Pedigree
- Risk Factors