Article
A method for estimating cancer risk in p53 mutation carriers.
Cancer detection and prevention - 1 Jan 1994
Le Bihan C, Bonaiti-Pellie C
Abstract excerpt
Germline mutations of the tumor-suppressor gene p53 have been described in families with multiple neoplasms as Li-Fraumeni syndrome families, or in subjects with second malignant tumor. In order to evaluate the increase in risk of cancer due to these mutations, a family study is being carried out. In families with a proband who developed a cancer before age 16, we select those with at least one cancer before age...
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