Article
Mutation of gene of mannose-binding protein associated with chronic hepatitis B viral infection.
Lancet (London, England) - 23 Nov 1996
Thomas H C, Foster G R, Sumiya M, McIntosh D, Jack D L, Turner M W, Summerfield J A
Abstract excerpt
BACKGROUND: Persistent with hepatitis B virus (HBV) affects 350 million people worldwide, and 20-40% of infected patients die of cirrhosis and liver cancer. Little is known about the host factors that determine the variable natural history. Studies have focused on the role of acquired rather than innate immunity. We have investigated the prevalence of mutations in the gene for mannose-binding protein (MBP), which...
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