Article
Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors.
Journal of the National Cancer Institute - 18 Jan 1995
Fitzgerald J M, Ramchurren N, Rieger K, Levesque P, Silverman M, Libertino J A, Summerhayes I C
Abstract excerpt
BACKGROUND: Urinary cytology has long been used as a noninvasive screen for the detection of urinary tract cancer but is limited by the generation of false positive and false negative results. More recently, molecular changes associated with urothelial neoplastic progression have been identified in DNA from urine sediments, demonstrating an alternative approach for identifying neoplastic change in the bladder....
Topics
- Base Sequence
- Biomarkers, Tumor
- DNA, Neoplasm
- Disease Progression
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Recurrence, Local
- Polymorphism, Single-Stranded Conformational