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Article

p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.

Cancer cytopathology - 1 Oct 2014

Piaton Eric, Casalegno Jean-Sébastien, Advenier Anne-Sophie, Decaussin-Petrucci Myriam, Mege-Lechevallier Florence, Ruffion Alain, Mekki Yahia

Abstract excerpt

BACKGROUND: p16(INK4a) Is overexpressed in almost all precancerous and carcinomatous lesions of the uterine cervix, secondary to interference between high-risk human papillomaviruses (hr-HPVs) and the retinoblastoma gene product. Overexpression of p16(INK4a) has also been identified in patients with high-grade urothelial lesions, both cytologically and histologically. However, the etiological role of HPV has not...

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PMID: 25069600
DOI: 10.1002/cncy.21462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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