Article
High cell kinetics is associated with amplification of the int-2, bcl-1, myc and erbB-2 proto-oncogenes and loss of heterozygosity at the DF3 locus in primary breast cancers.
International journal of cancer - 29 Mar 1995
Contegiacomo A, Pizzi C, De Marchis L, Alimandi M, Delrio P, Di Palma E, Petrella G, Ottini L, French D, Frati L
Abstract excerpt
Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and...
Topics
- Adult
- Aged
- Breast Neoplasms
- Cell Cycle
- Female
- Gene Amplification
- Gene Deletion
- Heterozygote
- Humans
- Middle Aged
- Mutation
- Proto-Oncogenes