Polymorphism of the pentanucleotide repeat d(AAAAT) within intron 1 of the human tumor suppressor gene p53 (17p13.1).

doi:10.1007/BF00208983

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Article

Polymorphism of the pentanucleotide repeat d(AAAAT) within intron 1 of the human tumor suppressor gene p53 (17p13.1).

Human genetics - 1 Apr 1995

Hahn M, Fislage R, Pingoud A

Abstract excerpt

DyeDeoxy terminator cycle sequencing of allele-specific polymerase chain reaction products has shown that there is a highly polymorphic d(AAAAT) pentanucleotide repeat within the first intron of the human p53 gene. This provides a genetic marker for tumor suppressor p53 gene alterations.

Topics

Alleles
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 17
DNA Primers
Gene Frequency
Genes, p53
Genetic Markers
Humans
Introns
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

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