Article
p53 gene analysis of ovarian borderline tumors and stage I carcinomas.
Human pathology - 1 Apr 1995
Kupryjanczyk J, Bell D A, Dimeo D, Beauchamp R, Thor A D, Yandell D W
Abstract excerpt
Mutations of the p53 gene are common in human ovarian carcinomas; however, their role in the early development of ovarian cancer is unclear. Twelve ovarian borderline tumors (BTs; eight of them p53 immunopositive) and 10 stage I carcinomas (four of them p53 immunopositive) were studied for genetic alterations in the p53 gene. The study was based on single-strand conformation polymorphism (SSCP) analysis and DNA...
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