The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

doi:10.1021/tx800473w

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Article

The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

Chemical research in toxicology - 1 Apr 2009

Turesky Robert J, Bendaly Jean, Yasa Isil, Doll Mark A, Hein David W

Abstract excerpt

2-amino-9H-pyrido[2,3-b]indole (AalphaC) is a carcinogenic heterocyclic aromatic amine (HAA) that is produced in high quantities in tobacco smoke and that also forms in charred meats. The bioactivation of AalphaC occurs by cytochrome P450-mediated (P450 1A2) N-oxidation of the exocyclic amine group, to form 2-hydroxyamino-9H-pyrido[2,3-b]indole (HONH-AalphaC). The HONH-AalphaC metabolite can then undergo further...

Topics

Animals
Arylamine N-Acetyltransferase
CHO Cells
Carbolines
Cell Line
Chromatography, Liquid
Cricetinae
Cricetulus
Cytochrome P-450 Enzyme System
DNA Adducts
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hypoxanthine Phosphoribosyltransferase

Mutagenesis

Phenotype

Polymorphism, Genetic

Spectrometry, Mass, Electrospray Ionization

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 19243127
DOI: 10.1021/tx800473w
PMCID: PMC2673018

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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